细胞发育与未来农业前沿论坛第63期

报告人：Prof. Jean-David Rochaix   瑞士日内瓦大学

报告题目：Retrograde Signaling

时间：2026年05月26日（星期二）10:00

地点：农业与生物学院A-103

邀请人：尹若贺  研究员

简介：

Jean-David Rochaix，教授是国际著名的植物生理学专家，欧洲科学院院士及欧洲分子生物学组织（EMBO）会员，2016年获国际光合作用研究会终身成就奖。他在光合作用与叶绿体研究领域成就卓著，已累计发表学术论著260余篇，其中Nature、Science、Cell >10篇。

Summary: Retrograde signaling is the process by which organelles such as chloroplasts and mitochondria send signals to the nucleus to modulate gene expression in response to developmental demands or environmental changes. These signals allow cells to coordinate nuclear transcription with organelle function, ensuring metabolic balance, stress adaptation and cell homeostasis. There are two types of retrograde signaling. Biogenic retrograde signaling sends signals from chloroplasts to the nucleus that regulate nuclear genes involved in chloroplast development and function. Operational retrograde signaling communicates the chloroplast status under various stress conditions using stress-related signaling molecules like reactive oxygen species and adjusts nuclear gene expression to manage stress and readjust metabolic activities.  Here, chloroplasts act as environmental sensors for light intensity and quality, drought and cold. Several putative retrograde signals have been identified including tetrapyrroles, ROS such as singlet oxygen and H2O2, oxidation products of carotenoids, terpenoids, proteins and peptides. Heme could be a prime candidate signal to promote the expression of genes required for chloroplast development. Treatments and mutations affecting chloroplast transcription, RNA editing, translation, or protein import all impact on the synthesis and/or processing of this signal. However several key questions remain open such as signal initiation in plastids, signal movement or transduction, signal perception in the cytosol and/or transduction to the nucleus leading to transcriptional or post transcriptional responses.