运用分子生物学、多组学、系统生物学等方法，解析与环境具有密切相互作用的复杂表型，特别是与线粒体密切相关的抗逆、衰老和发育等相关表型。
1. 植物发育及逆境中的线粒体逆向信号
2. 线粒体来源信号调节个体与细胞衰老的机制
3. 系统生物学在植物线粒体和细胞代谢研究中的应用
研究论文
Liu M, Sun W, Li C, Yu G, Li J, Wang Y, Wang Xu. A multilayered cross-species analysis of GRAS transcription factors uncovered their functional networks in plant adaptation to the environment. Journal of Advanced Research. 2021; 29: 191-205. (IF= 10.479)
Sleiman MB, Jha P, Houtkooper R, Williams R, Wang X*, Auwerx J*. The gene regulatory footprint of aging highlights conserved central regulators. Cell Reports. 2020: 32(13):108203. (IF= 9.423)
Liu M#, Sun W#, Ma Z, Yu G, Li J, Wang Y, Wang Xu. Comprehensive multiomics analysis reveals key roles of NACs in plant growth and development and its environmental adaption mechanism by regulating metabolite pathways. Genomics. 2020; 112: 4897-4911. (IF= 5.736)
Oppi S, Nusser-Stein S, Blyszczuk P, Wang X, Jomard A, Marzolla V, Yang K, Velagapudi S, Ward LJ, Yuan XM, Geiger MA, Guillaumon AT, Othman A, Hornemann T, Rancic Z, Ryu D, Oosterveer MH, Osto E, Lüscher TF, Stein S. Macrophage NCOR1 protects from atherosclerosis by repressing a pro-atherogenic PPARγ signature. European Heart Journal. 2020; 41: 995-1005. (IF=22.673)
Houzelle A, Dahlmans D, Nascimento EBM, Schaart G, Jörgensen JA, Moonen-Kornips E, Kersten S, Wang X, Hoeks J. MicroRNA-204-5p modulates mitochondrial biogenesis in C2C12 myotubes and associates with oxidative capacity in humans. Journal of Cellular Physiology. 2020: 1-13. (IF=6.384)
Dahlmans D, Houzelle A, Andreux P, Wang X, Jorgensen JA, Moullan N, Daemen S, Kersten S, Auwerx J, Hoeks J. MicroRNA-382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells. Journal of Cellular Physiology 2019; 234: 6601-6610. (IF=6.384)
Li H#, Wang X#, Rukina D, Huang Q, Lin T, Sorrentino V, Zhang H, Sleiman MB, Arends D, McDaid A, Luan P, Ziari N, Velázquez-Villegas LA, Gariani K, Kutalik Z, Schoonjans K, Radcliffe RA, Prins P, Morgenthaler S, Williams RW, Auwerx J. An integrated systems genetics and omics toolkit to probe gene function. Cell Systems 2018; 6: 90-102. (IF=10.304)
Wang X & Auwerx J. Systems phytohormone responses to mitochondrial proteotoxic stress. Molecular Cell 2017; 68: 540-51. (IF=17.97)
Stein S#, Lemos V#, Xu P, Demagny H, Wang X, Ryu D, Jimenez V, Bosch F, Lüscher TF, Oosterveer MH, Schoonjans K. Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease. Journal of Clinical Investigation. 2017; 127(2):583-592. (IF=14.808)
Greggio C#, Jha P#, Kulkarni SS#, Lagarrigue S, Broskey NT, Boutant M, Wang X, Conde Alonso S, Ofori E, Auwerx J*, Cantó C*, Amati F*. Enhanced respiratory chain supercomplex formation in response to exercise in human skeletal muscle. Cell Metabolism. 2017; 25(2):301-311. (IF=27.287)
Dahlmans D, Houzelle A, Andreux P, Jörgensen J A., Wang X, de Windt L J., Schrauwen P, Auwerx J, Hoeks J. An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism. Molecular Metabolism. 2017; 6(11):1429-1442. (IF=7.422)
Luo J, Wang X, Feng L, Li Y, He JX. The mitogen-activated protein kinase kinase 9 (MKK9) modulates nitrogen acquisition and anthocyanin accumulation under nitrogen-limiting condition in Arabidopsis. Biochem Biophys Res Commun. 2017; 487(3):539-544. (IF=2.985)
Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, D'Amico D, Ropelle ER, Lutolf MP, Aebersold R, Schoonjans K, Menzies KJ*, Auwerx J*. NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science. 2016; 352(6292):1436-43. (IF=47.728)
Ryu D#, Zhang H#, Ropelle ER#, Sorrentino V, Mázala DA, Mouchiroud L, Marshall PL, Campbell MD, Ali AS, Knowels GM, Bellemin S, Iyer SR, Wang X, Gariani K, Sauve AA, Cantó C, Conley KE, Walter L, Lovering RM, Chin ER, Jasmin BJ, Marcinek DJ, Menzies KJ*, Auwerx J*. NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Science Translational Medicine. 2016; 8(361):361ra139. (IF=17.956)
Gariani K#, Menzies KJ#, Ryu D, Wegner CJ, Wang X, Ropelle ER, Moullan N, Zhang H, Perino A, Lemos V, Kim B, Park YK, Piersigilli A, Pham TX, Yang Y, Ku CS, Koo SI, Fomitchova A, Cantó C, Schoonjans K, Sauve AA, Lee JY, Auwerx J. Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice. Hepatology. 2016; 63(4):1190-204. (IF=17.425)
Xu P, Oosterveer MH, Stein S, Demagny H, Ryu D, Moullan N, Wang X, Can E, Zamboni N, Comment A, Auwerx J, Schoonjans K. LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer. Genes & Development. 2016; 30(11):1255-60. (IF=11.361)
Jha P, Wang X, Auwerx J. Analysis of mitochondrial respiratory chain supercomplexes using blue native polyacrylamide gel electrophoresis (BN-PAGE). Curr Protoc Mouse Biol. 2016 Mar 1;6(1):1-14